3D traction stresses activate protease-dependent invasion of cancer cells.

Abstract

Cell invasion and migration that occurs, for example, in cancer metastasis is rooted in the ability of cells to navigate through varying levels of physical constraint exerted by the extracellular matrix. Cancer cells can invade matrices in either a protease-independent or a protease-dependent manner. An emerging critical component that influences the mode… (More)
DOI: 10.1016/j.bpj.2014.07.078

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