3D structure of amyloid protofilaments of beta2-microglobulin fragment probed by solid-state NMR.

@article{Iwata20063DSO,
  title={3D structure of amyloid protofilaments of beta2-microglobulin fragment probed by solid-state NMR.},
  author={Kentaro Iwata and Toshimichi Fujiwara and Yoh Matsuki and Hideo Akutsu and Satoshi Takahashi and Hironobu Naiki and Yuji Goto},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 48},
  pages={18119-24}
}
Understanding the structure and formation of amyloid fibrils, the filamentous aggregates of proteins and peptides, is crucial in preventing diseases caused by their deposition and, moreover, for obtaining further insight into the mechanism of protein folding and misfolding. We have combined solid-state NMR, x-ray fiber diffraction, and atomic force microscopy to reveal the 3D structure of amyloid protofilament-like fibrils formed by a 22-residue K3 peptide (Ser(20)-Lys(41)) of beta(2… CONTINUE READING
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