3D structure-based protein retention prediction for ion-exchange chromatography.

@article{Dismer20103DSP,
  title={3D structure-based protein retention prediction for ion-exchange chromatography.},
  author={Florian Dismer and J{\"u}rgen Hubbuch},
  journal={Journal of chromatography. A},
  year={2010},
  volume={1217 8},
  pages={1343-53}
}
The interest in understanding fundamental mechanisms underlying chromatography drastically increased over the past decades resulting in a whole variety of mostly semi-empirical models describing protein retention. Experimental data about the molecular adsorption mechanisms of lysozyme on different chromatographic ion-exchange materials were used to develop a mechanistical model for the adsorption of lysozyme onto a SP Sepharose FF surface based on molecular dynamic simulations (temperature… CONTINUE READING

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