3D structure analysis of PAKs A clue to the rational design for affinity reagents and blockers

@inproceedings{Jha20123DSA,
  title={3D structure analysis of PAKs A clue to the rational design for affinity reagents and blockers},
  author={Ramesh Kumar Jha and Charlie E. M. Strauss},
  year={2012}
}
The p21-activated kinase (PAK) family plays a versatile role in cell signaling by forming a hub of interactions. PAKs bind the GTPases like RAC and CDC42. Their proline-rich motifs bind SH3 adaptor proteins such as PIX and NCK. PAKs display nuclear localization signal sites and a potential Integrin binding site. No fully complete structure of the PAKs has been published; partial 3D structures of the PAK family kinases include portions of the auto-inhibited PAK1, GTPase bound to small peptides… CONTINUE READING

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The PAKs come of age

  • Cellular logistics
  • 2012
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