3D printing of nanocellulose hydrogel scaffolds with tunable mechanical strength towards wound healing application.

@article{Xu20183DPO,
  title={3D printing of nanocellulose hydrogel scaffolds with tunable mechanical strength towards wound healing application.},
  author={Chunlin Xu and Binbin Zhang Molino and Xiaoju Wang and Fang Cheng and Wenyang Xu and Paul J. Molino and Markus Bacher and Dandan Su and Thomas Rosenau and Stefan Willf{\"o}r and Gordon G. Wallace},
  journal={Journal of materials chemistry. B},
  year={2018},
  volume={6 43},
  pages={
          7066-7075
        }
}
We present for the first time approaches to 3D-printing of nanocellulose hydrogel scaffolds based on double crosslinking, first by in situ Ca2+ crosslinking and post-printing by chemical crosslinking with 1,4-butanediol diglycidyl ether (BDDE). Scaffolds were successfully printed from 1% nanocellulose hydrogels, with their mechanical strength being tunable in the range of 3 to 8 kPa. Cell tests suggest that the 3D-printed and BDDE-crosslinked nanocellulose hydrogel scaffolds supported… 
View on PubMed
rsc.org
66 Citations
Highly Influential Citations
3
Background Citations
10
Methods Citations
9

66 Citations

Citation Type

Citation Type

3D Bioprinted Nanocellulose-Based Hydrogels for Tissue Engineering Applications: A Brief Review
TLDR
The most recent key developments and challenges in 3D bioprinting nanocellulose-based hydrogel constructs that have been successfully tested for mammalian cell viability and used in tissue engineering applications are discussed.
3D bioprinting of dual-crosslinked nanocellulose hydrogels for tissue engineering applications.
TLDR
The dual crosslinkable hydrogel ink herein developed is versatile, easy to prepare, and suitable for 3D printing of bioscaffolds with highly tailored viscoelastic and mechanical properties applicable in a wide range of regenerative medicines.
Stepwise Cross-Linking of Fibroin and Hyaluronic for 3D Printing Flexible Scaffolds with Tunable Mechanical Properties.
TLDR
For the first time, this strategy achieves 3D printing of natural biomaterials with controlled mechanical characteristics by manipulating the cross-linking of peptide chains in a shear-thinning hydrogel.
A 3D-printable TEMPO-oxidized bacterial cellulose/alginate hydrogel with enhanced stability via nanoclay incorporation.
Nanocellulose based hydrogel or aerogel scaffolds for tissue engineering
TLDR
This review presents an in-depth discussion of the roles of nanocellulose in skin, bone, vessel, cartilage, soft tissue, muscle, heart and tooth hydrogel or aerogel scaffolds.
Advances in tissue engineering of nanocellulose-based scaffolds: A review.
Synthesis and characterization of photocrosslinkable albumin-based hydrogels for biomedical applications.
TLDR
The biocompatibility and degradability of the material demonstrated effective integration with the native tissue environment and modifiable chemical and mechanical properties allow BSA hydrogels to be fine-tuned to a plethora of biomedical applications including regenerative medicine, in vitro cancer study models, and wound healing approaches.
Multifunctional hydrogels for wound healing: Special focus on biomacromolecular based hydrogels.
Acetylated Nanocellulose for Single-Component Bioinks and Cell Proliferation on 3D-Printed Scaffolds
TLDR
The performance of acetylated nanocellulose bioinks opens the possibility for reliable and scale-up fabrication of scaffolds appropriate for studies on cellular processes and for tissue engineering.
On Low-Concentration Inks Formulated by Nanocellulose Assisted with Gelatin Methacrylate (GelMA) for 3D Printing toward Wound Healing Application
TLDR
The developed low-concentration CNF/GelMA formulations with a facile yet effective approach to fabricate scaffolds showed great potential in 3D printing for wound healing application.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 40 REFERENCES
Development of nanocellulose scaffolds with tunable structures to support 3D cell culture.
Cytocompatibility of Wood-Derived Cellulose Nanofibril Hydrogels with Different Surface Chemistry.
TLDR
The porous fibrous structure may be a key to cell proliferation and migration in the hydrogels, and direct cytotoxicity tests showed no toxic effect of either hydrogel.
3D Bioprinting Human Chondrocytes with Nanocellulose-Alginate Bioink for Cartilage Tissue Engineering Applications.
TLDR
A bioink that combines the outstanding shear thinning properties of nanofibrillated cellulose (NFC) with the fast cross-linking ability of alginate with the potential use of nanocellulose for 3D bioprinting of living tissues and organs is formulated.
Novel multifunctional PB and PBH hydrogels as soft filler for tissue engineering.
TLDR
The PB and PBH hydrogels were found to be acceptable, safe, soft materials for use in skin restoration, cartilage treatment, and lacrimal dryness therapy.
An injectable scaffold based on crosslinked hyaluronic acid gel for tissue regeneration
TLDR
The feasibility of this HAG, as an injectable scaffold, to regenerate cartilage and dentin–pulp complex was demonstrated using a preliminary subcutaneous microenvironment and could be a reference to take account of how a crosslinked HA gel should be chosen for specific tissue regeneration.
Solidification of 3D Printed Nanofibril Hydrogels into Functional 3D Cellulose Structures
Cellulose nanofibrils isolated from trees have the potential to be used as raw material for future sustainable products within the areas of packaging, textiles, biomedical devices, and furniture.…
Hemicellulose-reinforced nanocellulose hydrogels for wound healing application
TLDR
These all-polysaccharide composite hydrogels may work as promising scaffolds in wound healing applications to provide supporting networks and to promote cells adhesion, growth, and proliferation.
Cellulose Nanofibers for the Enhancement of Printability of Low Viscosity Gelatin Derivatives
Inadequate rheological properties of gelatin methacrylamide (GelMA) were successfully improved by incorporating cellulose nanofibers (CNFs), such that the printed scaffolds could maintain their…
Injectable Alginate Hydrogel Cross-Linked by Calcium Gluconate-Loaded Porous Microspheres for Cartilage Tissue Engineering
A great interest has been shown in the injectable scaffolds for cartilage tissue regeneration because it can fill irregularly shaped defects easily through minimally invasive surgical treatments.…
Fiber-reinforced scaffolds in soft tissue engineering
TLDR
The concept of fiber-reinforced scaffolds with adjustable microstructures, mechanical properties and degradation rates can provide an effective platform and promising method for developing satisfactory biomechanically functional implantations for soft tissue engineering or regenerative medicine.
...
1
2
3
4
...