3D-printed microfluidic chips with patterned, cell-laden hydrogel constructs

@article{Knowlton20163DprintedMC,
  title={3D-printed microfluidic chips with patterned, cell-laden hydrogel constructs},
  author={Stephanie Knowlton and Chu Hsiang Yu and Fulya Ersoy and Sharareh Emadi and Ali Khademhosseini and Savas Tasoglu},
  journal={Biofabrication},
  year={2016},
  volume={8}
}
Three-dimensional (3D) printing offers potential to fabricate high-throughput and low-cost fabrication of microfluidic devices as a promising alternative to traditional techniques which enables efficient design iterations in the development stage. In this study, we demonstrate a single-step fabrication of a 3D transparent microfluidic chip using two alternative techniques: a stereolithography-based desktop 3D printer and a two-step fabrication using an industrial 3D printer based on polyjet… 
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108 Citations
Background Citations
8
Methods Citations
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108 Citations

A 3D printed microfluidic perfusion device for multicellular spheroid cultures

A proof-of-concept in simplifying and integrating the prototyping and operation of a microfluidic spheroid culture device, which will facilitate its applications in various drug efficacy, metabolism and toxicity studies.

Accessing microfluidics through feature-based design software for 3D printing

The production of multiple microfluidic architectures using a hybrid 3D printing-soft lithography approach is demonstrated and shown to enable rapid device fabrication with channel dimensions that take advantage of laminar flow characteristics.

Sealing 3D-printed parts to poly(dimethylsiloxane) for simple fabrication of Microfluidic devices.

3D-Printed Microfluidics and Potential Biomedical Applications

3D printing is a smart additive manufacturing technique that allows the engineering of biomedical devices that are usually difficult to design using conventional methodologies such as machining or…

Fabrication of truly 3D microfluidic channel using 3D-printed soluble mold.

The use of three-dimensional printed soluble wax as cast molds for rapid fabrication of truly arbitrary microfluidic polydimethylsiloxane (PDMS) channels that are not achieved through typical soft lithography is introduced.

3D printed microfluidic devices: a review focused on four fundamental manufacturing approaches and implications on the field of healthcare

In the last few years, 3D printing has emerged as a promising alternative for the fabrication of microfluidic devices, overcoming some of the limitations associated with conventional…

3D printed microfluidic devices: a review focused on four fundamental manufacturing approaches and implications on the field of healthcare

In the last few years, 3D printing has emerged as a promising alternative for the fabrication of microfluidic devices, overcoming some of the limitations associated with conventional…

The crossing and integration between microfluidic technology and 3D printing for organ-on-chips.

The combination of 3D printing and microfluidic technology in organ-on-chips provides a more efficient choice for building complex flow channels or chambers, as well as the ability to create biological structures with a 3D cell distribution, heterogeneity and tissue-specific function.

Projection-Based 3D Printing of Cell Patterning Scaffolds with Multiscale Channels.

A projection-based 3D printing system that achieves rapid and high-resolution fabrication of hydrogel scaffolds featuring intricate channels for multiscale cell patterning, and shows that red fluorescent protein-transfected A549 human nonsmall lung cancer cells adhered well in the scaffolds' channels, and showed further attachment and penetration during cell culture proliferation.

Can 3D Printing Bring Droplet Microfluidics to Every Lab?—A Systematic Review

It is concluded that today, 3D printers could already be used in every research lab and printing droplet microfluidics is also a possibility, albeit with some challenges discussed in this review.
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References

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