3D position of pericentromeric heterochromatin within the nucleus of a patient with ICF syndrome.

Abstract

ICF (immunodeficiency, centromeric region instability, facial anomalies) syndrome is a rare autosomal recessive disorder characterised by severe immunodeficiency, craniofacial anomalies and chromosome instability. Chromosome analyses from blood samples show a high frequency of decondensation of pericentromeric heterochromatin (PH) and rearrangements… (More)
DOI: 10.1111/j.1399-0004.2011.01697.x

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