3D modeling of the activated states of constitutively active mutants of rhodopsin.

@article{Nikiforovich20063DMO,
  title={3D modeling of the activated states of constitutively active mutants of rhodopsin.},
  author={Gregory V. Nikiforovich and Garland R. Marshall},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={345 1},
  pages={430-7}
}
The activated (R*) states in constitutively active mutants (CAMs) of G-protein-coupled receptors (GPCRs) are presumably characterized by lower energies than the resting (R) states. If specific configurations of TM helices differing by rotations along the long transmembrane axes possess energies lower than that in the R state for pronounced CAMs, but not for non-CAMs, these particular configurations of TM helices are candidate 3D models for the R* state. The hypothesis was studied in the case of… CONTINUE READING