3D culture increases pluripotent gene expression in mesenchymal stem cells through relaxation of cytoskeleton tension

Abstract

Three-dimensional (3D) culture has been shown to improve pluripotent gene expression in mesenchymal stem cells (MSCs), but the underlining mechanisms were poorly understood. Here, we found that the relaxation of cytoskeleton tension of MSCs in 3D culture was critically associated with the expressional up-regulation of Nanog. Cultured in spheroids, MSCs… (More)
DOI: 10.1111/jcmm.12946

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Cite this paper

@inproceedings{Zhou20173DCI, title={3D culture increases pluripotent gene expression in mesenchymal stem cells through relaxation of cytoskeleton tension}, author={Ying Zhou and Haiyan Chen and Hong Bo Li and Yaojiong Wu}, booktitle={Journal of cellular and molecular medicine}, year={2017} }