3D-QSAR study on VEGFR kinase inhibition of aminopyrazolopyridine urea derivatives by CoMFA and CoMSIA


Three-dimensional quantitative structure–activity relationship has been performed on 28 aminopyrazolopyridine ureas derivatives to correlate their chemical structures with their observed VEGFR kinase inhibitory activity. The studies include comparative molecular field analysis (CoMFA), CoMFA region focusing and comparative molecular similarity indices… (More)
DOI: 10.1007/s00044-014-0933-0


7 Figures and Tables