3BP2 deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation.

@article{Fuente20063BP2DI,
  title={3BP2 deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation.},
  author={Miguel A de la Fuente and Lalit Kumar and Bao Lu and Raif S Geha},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 14},
  pages={5214-25}
}
The adapter protein 3BP2 is expressed in lymphocytes; binds to Syk/ZAP-70, Vav, and phospholipase C-gamma (PLC-gamma); and is thought to be important for interleukin-2 gene transcription in T cells. To define the role of 3BP2 in lymphocyte development and function, we generated 3BP2-deficient mice. T-cell development, proliferation, cytokine secretion, and signaling in response to T-cell receptor (TCR) ligation were all normal in 3BP2(-/-) mice. 3BP2(-/-) mice had increased accumulation of pre… CONTINUE READING

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