372 Susceptibility to Phenytoin-induced Cleft Palate in Mice Correlated with Inhibition of Fetal Palatal Rna and Protein Synthesis

Phenytoin, an anticonvulsant which is commonly used in the treatment of epilepsy, is teratogenic in humans and produces cleft palate in susceptible rodents. We therefore investigated the effects of a teratogenic dose (50 mg/kg,S.C.) of phenytoin in the susceptible Ajax (A/J) and the resistant C57BL6 (B6) inbred strains of mice during the critical period of… CONTINUE READING