364 Phaemacokinetic Evaluation of Trimethoprim-sulfameth-oxazole(tmp-smx) in Patients with Cystic Fibrosis(cf)


The first dose (FD) and steady state (SS) pharmacokinetics of orally administered TMP-SMX was evaluated in 15 patients with CF. The biodisposition of the TMP and SMX were regulated independently and no fixed ratio of the TMP to SMX was maintained. The FD and SS pharmacokinetic parameters for TMP were determined using a single compartment model. Data are… (More)
DOI: 10.1203/00006450-198104001-00375


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