- 361-Muscle Wasting and IL-6

  title={- 361-Muscle Wasting and IL-6},
  author={Toshimasa Tsujinaka and Chikara Ebisui and Junya Fujita and Masanori Kishibuchi and Masahiko Yano},
Muscle wasting is a common feature of systemic inflammation and malignant diseases. The primary cause is accelerated proteolysis. Protein degradation was found to be accelerated by IL-6 with activation of intracellular proteases in C2C12 myotubes. IL-6 transgenic mice displayed extensive muscle wasting together with an increase of proteolytic pathways. The increase in activities and mRNA levels of cathepsins (B and L) and the poly-ubiquitin (Ub) mRNA level could be inhibited by treatment with… CONTINUE READING