348 CASES OF SUSPECTED NEONATAL ALLOIMMUNE THROMBOCYTOPENIA

@article{MuellerEckhardt1989348CO,
  title={348 CASES OF SUSPECTED NEONATAL ALLOIMMUNE THROMBOCYTOPENIA},
  author={Ch. Mueller-Eckhardt and Alfons Grubert and M Weisheit and Gertrud Mueller‐Eckhardt and Volker Kiefel and Hartmut Kroll and Sabine Schmidt and Sentot Santoso},
  journal={The Lancet},
  year={1989},
  volume={333},
  pages={363-366}
}
Serological and clinical data were collected in 348 cases of suspected neonatal alloimmune thrombocytopenia (NAT). Of the 144 mothers who were Zwa-negative, 107 had Zwa antibodies--alone (94); with HLA antibodies (12); or with Bra antibodies (1). Antibodies were detected in 12 of the 204 Zwa-positive mothers as follows: anti-Bra (9), anti-Zwb (1), anti-Baka with HLA antibody (1), and blood group B isoagglutinins (1). The frequency of NAT due to Bra incompatibility (19%) was second to Zwa (78… Expand
Neonatal Immune Thrombocytopenia Due to Allo-or Autoantibodies: Clinical and Immunological Analysis of 83 Cases.
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The findings of a high frequency (45%) of maternal anti-HLA antibodies in the HPA-la positive group, suggests an association of NAIT and maternal HLA alloimmunisation, and the finding of circulating platelet autoantibodies makes it possible that these women are suffering from compensated AITP. Expand
Anti-HPA-3A induces severe neonatal alloimmune thrombocytopenia.
TLDR
AIT caused by incompatibility of HPA-3a is similar in severity to disease caused by compatibility of H PA-1a, and affected families should be appropriately counseled and considered for antenatal therapy. Expand
HPA‐5b (Bra) neonatal alloimmune thrombocytopenia: clinical and immunological analysis of 39 cases
TLDR
The mothers of a previously affected child should be managed similarly to the HPA‐1b mothers (PIA2, Zwb), and the antenatal diagnosis of thrombocytopenia should be made and if necessary the in utero therapy instituted. Expand
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TLDR
A male baby, who was admitted for low birth weight with Down syndrome, was suffered from thrombocytopenia without transient myeloproliferative disorder (TMD), and positive reactions of HLA-specific antibodies were detected in maternal serum. Expand
Delayed severe HPA-5b neonatal alloimmune thrombocytopenia: A case report
  • P. Moncharmont, M. Vignal, Y. Mérieux, D. Rigal
  • Medicine
  • The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2007
TLDR
This report considers a case of delayed anti-HPA-5b thrombocytopenia with ICH requiring platelet transfusion, manifested five days after birth. Expand
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TLDR
The data indicate that an immune origin is frequent in NNT and should be looked for, particularly when the platelet count is <“50”× 109/l,” and that the difference was significant between the control groups and the group of mothers of thrombocytopenic newborns. Expand
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TLDR
This study can provide insights for diagnosing prospective cases of neonatal alloimmune thrombocytopenia caused by anti HPA-3a antibody and prognosis of NAIT caused by HPA3a seems to be favorable if diagnosed and treated in a timely manner. Expand
Severe Neonatal Alloimmune Thrombocytopenia due to Anti-HPA-3a
TLDR
Severe neonatal thrombocytopenia associated with HPA-3a alloimmunization is infrequent and all the factors mentioned above could have played a role in the severity of the disease. Expand
Anti-Bak(a) neonatal alloimmune thrombocytopenia: possible prevention by intravenous immunoglobulin.
TLDR
The case of a mother whose first three infants developed NAIT secondary to anti-Bak(a) antibodies, while her fourth infant did not, and the single dose of intravenous immunoglobulin (IVIg) given to the mother is described, raises several questions. Expand
The natural history of maternal immunization against foetal platelet alloantigens
TLDR
Generalized purpura due to FMAIT occurs in one in 9359 (95% CI: 1 in 77 519–1 in 2591) pregnancies solely because of HPA‐4b incompatibility, and two neonates born to mothers having anti‐HPA‐ 4b developed generalized purpURA. Expand
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