34: Expression and function of ADAR1 and PACT and their impact on PKR activation during HIV-1 infection

@inproceedings{Daher201434EA,
  title={34: Expression and function of ADAR1 and PACT and their impact on PKR activation during HIV-1 infection},
  author={A{\"i}cha Daher and Samantha Burugu and Guerline Clerzius and Eileen Shaw and Roman Radetskyy and Jean-Pierre Routy and Anne Gatignol},
  year={2014}
}
Aims A poor innate immune response contributes to the establishment of viral latency and persistence in human immunodeficiency virus (HIV)-1 infection. The protein kinase RNA-activated (PKR) is an Interferon-stimulated gene (ISG) that senses RNA viruses. PKR is a potent HIV-1 suppressor through the phosphorylation of the translation initiation factor eIF2 α and consequent inhibition of protein synthesis. We showed that PKR is activated at the beginning of HIV-1 infection followed by a… CONTINUE READING