328 Theophylline Metabolism by the Human Premature Infant

The excretion of theophylline and its metabolites was studied in 8 premature infants treated for apnea. Changes and differences in metabolic patterns were sought. Theophylline and metabolites were assayed in urine and serum by HPLC. Urine was passed through a Dowex-2 column for clean-up prior to injection. Recovery of compounds by this method was >95%. In 6… CONTINUE READING