31P magnetic resonance spectroscopy as a predictor of efficacy in photodynamic therapy using differently charged zinc phthalocyanines

@article{Bremner199931PMR,
  title={31P magnetic resonance spectroscopy as a predictor of efficacy in photodynamic therapy using differently charged zinc phthalocyanines},
  author={Jane C. M. Bremner and Simon T Wood and James Frederick Bradley and J. F. Griffiths and Grace Elizabeth Mary Adams and Stanley B. Brown},
  journal={British Journal of Cancer},
  year={1999},
  volume={81},
  pages={616 - 621}
}
Photodynamic therapy (PDT) is a developing approach to the treatment of solid tumours which requires the combined action of light and a photosensitizing drug in the presence of adequate levels of molecular oxygen. We have developed a novel series of photosensitizers based on zinc phthalocyanine which are water-soluble and contain neutral (TDEPC), positive (PPC) and negative (TCPC) side-chains. The PDT effects of these sensitizers have been studied in a mouse model bearing the RIF-1 murine… CONTINUE READING
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