31P NMR studies in Duchenne muscular dystrophy: age-related metabolic changes.

@article{Younkin198731PNS,
  title={31P NMR studies in Duchenne muscular dystrophy: age-related metabolic changes.},
  author={Donald P Younkin and Peter Berman and J. Sladky and C. F. Y. Chee and William Easterly World Bank and Britton Chance},
  journal={Neurology},
  year={1987},
  volume={37 1},
  pages={165-9}
}
To evaluate possible progressive metabolic changes in Duchenne muscular dystrophy, we used 31P nuclear magnetic resonance spectroscopy to measure high-energy phosphate compounds and phosphorylated diesters (PDE) in resting gastrocnemius muscle of 14 Duchenne patients and 10 normal boys. The patients had higher inorganic phosphate (Pi), intracellular pH, and PDE; and lower phosphocreatine (PCr) and PCr/Pi ratio; ATP was not significantly different. The patients showed significant age-related… CONTINUE READING

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