3143 A new biometerial for intraocular lens. Experimental in vivo study

Abstract

Purpose: To evaluate the course of diabetic patients having performed cataract-surgery by an ex@enced surgeon using phacoemulshicationtechnique and the implantation of a hepariucoated posterior chamber lens. Cataract-surgery is often complicated with the development of macular edema and the aggravation of diabetic retinopathy. Even patients with no clinically detectable diabetic retinopathy are, &I cataract-surgery, iu a higher risk of developing macular edema than non-diabetics. Method: The study is retrospective, evahvatiag the course of 40 diabetic eyes. The results are compared to a sexand age-matched group of ncmdiabetic controls. All patients are operated by the same ea@enced surgeon, all are operated with the phacoem&ilication-technique, but the lens-type is not necessarily B hepaiucoated type iu the non-diabetic controls. As a result of the lenient procedure, using a small-i&donmethod, an experienced surgeon and the implantation of a lens-type, which has proved to induce less postsurgical in&wmnation, the impairment ofthe blood-retina-barrier is thought to be less. Results: We WiIL present the case-records ofpatients (40 eyes in each group) operated with this procedure in 1992, 1993 and the tist six months of 1994. Duration and type of diabetes, medication, hypertension, surgical complications, type of retiuopathy, lasertreatment, and visual improvement is registered. Conflusioo: the results will be presented at the meeting. Purpose We performed and evaluated a novel transparent fluorocarbon polymer for IOL The biomaterial is transparent and is highly hydrophobic The polymer have important antiadhesive surface quality and could be used as HSM PMMA IGL Materials PMMA IOL ‘lens-with 6 mm optic of diameter was modified and coated with a thickness of 1 to 2 urn of fluorocarbon layer The fluorocarbon polymer was investigatkd by Raman and Infrared spectrometry, solid NMR, X ray microanalysis and the surface of the fluorocarbon coating was controlled by Scanning electron microscopy (SEM) We implanted 25 New Zealand Rabbit weighting 2 5 to 3 Kg The implantation were performed after phakoemulsification. 20 rabbits were implanted with the PMh4A/Fluorocarbon lens and 5 with regular PMMA lens and were removed after 3 months follow-up &III& We are able to obtained permanent PMMA coating with this new inert fluorocarbon polymer However, by SEM we observed several irregularity on coated PMMA lens. We observed no clinical intlammatoly response in 19 rabbits One endophtalmitis was observed in the first 3 days and was successfully treated with local antibiotic None iris implant-adhesion were observed on the 20 coated implants, on contrary 415 PMMA lens control shows important iris PMMA-adhesion Capsule opacification was observed in the first hvo or three months after phakoemulsification After IOL explantation, SEM observation shows no inflammatory cells or giant cells m contact with the fluorocarbon Some fibroblast was observed on smallirregular surface Conclusions First in viva study demonstrated the high biocompatibility of the transparent fluorocarbon polymer and it’s strong antiadhesive capacity

DOI: 10.1016/0042-6989(95)90270-8

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@article{Legeais19953143AN, title={3143 A new biometerial for intraocular lens. Experimental in vivo study}, author={J. M. Legeais and Lauryn Werner and Benoit Briat and Didier Th{\'e}venin and G. Renard and Yves Pouliquen}, journal={Vision Research}, year={1995}, volume={35} }