30 Years Later – a New Approach to Sol Spiegelman's and Leslie Orgel's in vitro EVOLUTIONARY STUDIES Dedicated to Leslie Orgel on the occasion of his 70th birthday

@article{Oehlenschlger200430YL,
  title={30 Years Later – a New Approach to Sol Spiegelman's and Leslie Orgel's in vitro EVOLUTIONARY STUDIES Dedicated to Leslie Orgel on the occasion of his 70th birthday},
  author={F. Oehlenschl{\"a}ger and M. Eigen},
  journal={Origins of life and evolution of the biosphere},
  year={2004},
  volume={27},
  pages={437-457}
}
  • F. Oehlenschläger, M. Eigen
  • Published 2004
  • Chemistry, Medicine
  • Origins of life and evolution of the biosphere
  • The conditions necessary for evolution are amplification, mutagenesis and selection. Here we describe the evolutionary response of an in vitro replicating system to the selection pressure for fast growth and show what happens to the amplified molecules within this replication system. Our emphasis is on methodology, on the monitoring and the automation of experiments in molecular evolution. In order to perform in vitro studies on the evolution of RNA molecules, a modified self-sustained sequence… CONTINUE READING
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