3-phosphoinositide-dependent protein kinase-1/Akt signaling represents a major cyclooxygenase-2-independent target for celecoxib in prostate cancer cells.

@article{Kulp20043phosphoinositidedependentPK,
  title={3-phosphoinositide-dependent protein kinase-1/Akt signaling represents a major cyclooxygenase-2-independent target for celecoxib in prostate cancer cells.},
  author={Samuel K. Kulp and Y Yang and Chin-Chun Hung and Kuen-Feng Chen and J Lai and Ping-Hui Tseng and Joseph W. Fowble and Patrick J Ward and C Chen},
  journal={Cancer research},
  year={2004},
  volume={64 4},
  pages={1444-51}
}
Regarding the involvement of cyclooxygenase-2 (COX-2)-independent pathways in celecoxib-mediated antineoplastic effects, the following two issues remain outstanding: identity of the non-COX-2 targets and relative contributions of COX-2-dependent versus -independent mechanisms. We use a close celecoxib analog deficient in COX-2-inhibitory activity, DMC (4-[5… CONTINUE READING