3-methylcholanthrene induces differential recruitment of aryl hydrocarbon receptor to human promoters.

@article{Pansoy20103methylcholanthreneID,
  title={3-methylcholanthrene induces differential recruitment of aryl hydrocarbon receptor to human promoters.},
  author={Andrea Pansoy and Shaimaa Ahmed and Eivind Valen and Albin Sandelin and Jason Matthews},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2010},
  volume={117 1},
  pages={90-100}
}
The aryl hydrocarbon receptor (AHR) is a ligand-activated protein that mediates the toxic actions of polycyclic aromatic and halogenated compounds. Identifying genes directly regulated by AHR is important in understanding the pathways regulated by this receptor. Here we used the techniques of chromatin immunoprecipitation and DNA microarrays (ChIP-chip) to detect AHR-bound genomic regions after 3-methylcholanthrene (3MC) treatment of T-47D human breast cancer cells. We identified 241 AHR-3MC… CONTINUE READING
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