3-iodothyroacetic acid, a metabolite of thyroid hormone, induces itch and reduces threshold to noxious and to painful heat stimuli in mice.

Abstract

BACKGROUND AND PURPOSE Itch is associated with increased sensitization to nociceptive stimuli. We investigated whether 3-iodothyroacetic acid (TA1), by releasing histamine, induces itch and increases sensitization to noxious and painful heat stimuli. EXPERIMENTAL APPROACH Itch was evaluated after s.c. administration of TA1 (0.4, 1.32 and 4 μg·kg(-1… (More)
DOI: 10.1111/bph.13032

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