3-hydroxyglutaric acid enhances glutamate uptake into astrocytes from cerebral cortex of young rats.

Abstract

A predominantly neurological presentation is common in patients with glutaric acidemia type I (GA-I). 3-hydroxyglutaric acid (3-OHGA), which accumulates in affected patients, has recently been demonstrated to play a central role in the neuropathogenesis of this disease. In the present study, we investigated the in vitro effects of 3-OHGA at concentrations… (More)

Topics

Cite this paper

@article{Frizzo20043hydroxyglutaricAE, title={3-hydroxyglutaric acid enhances glutamate uptake into astrocytes from cerebral cortex of young rats.}, author={Marcos Em{\'i}lio Frizzo and Carolina Schwarzbold and Lisiane de Oliveira Porci{\'u}ncula and Karina Borges Dalcin and Rafael Borba Rosa and C{\'e}sar Augusto Jo{\~a}o Ribeiro and Diogo Onofre Souza and Moacir Wajner}, journal={Neurochemistry international}, year={2004}, volume={44 5}, pages={345-53} }