3-hydroxybutyrate blocks the transient K+ outward current in myocardial mouse cells in a stereoselective fashion.

@article{Doepner19973hydroxybutyrateBT,
  title={3-hydroxybutyrate blocks the transient K+ outward current in myocardial mouse cells in a stereoselective fashion.},
  author={Bettina Doepner and Stephan Thierfelder and Hj. Hirche and Klaus Benndorf},
  journal={The Journal of physiology},
  year={1997},
  volume={500 ( Pt 1)},
  pages={85-94}
}
1. Mouse ventricular myocytes develop a large transient K+ outward current (I(TO)) which accelerates repolarization and is a crucial determinant for the regulation of the action potential duration at various heart rates. The effect of 3-hydroxybutyrate on I(TO) was investigated under voltage- and current-clamp conditions. 2. The drug blocked I(TO) in a stereoselective manner with the L-enantiomer being the effective and the D-enantiomer, the ineffective form. The blocking action of the L… CONTINUE READING