3-hydroxy 3-methylglutaryl coenzyme A reductase increase is essential for rat muscle differentiation.


3-Hydroxy 3-methylglutaryl coenzyme A reductase (HMG-CoAR) is the key and rate-limiting enzyme of cholesterol biosynthetic pathway. Although HMG-CoAR activity has already been related to the differentiation of some cellular lines there are no studies that analyze the role of HMG-CoAR, and the pathway it is involved with in a fully characterized muscle… (More)
DOI: 10.1002/jcp.21810