3-chloromethylene-6-fluorothiochroman-4-one, A novel DNA Topoisomerase poison.

Abstract

3-Chloromethylene-6-fluorothiochroman-4-one (CMFT) is a novel thiochromanones derivative that has better anti-tumor activity. In this paper, we will compare the antitumor activity of the cis-trans isomers, and explore their inhibiting effects on human topoisomerase I and topoisomerase II in cell free reaction system. The MTT method was used to study… (More)

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.