3-aminopyrazolopyrazine derivatives as spleen tyrosine kinase inhibitors.

@article{Shen20163aminopyrazolopyrazineDA,
  title={3-aminopyrazolopyrazine derivatives as spleen tyrosine kinase inhibitors.},
  author={Jiayi Shen and Xiaokai Li and Zhang Zhang and Jingfeng Luo and Huoyou Long and Zheng-chao Tu and Xiaoping Zhou and Ke Ding and Xiaoyun Lu},
  journal={Chemical biology & drug design},
  year={2016},
  volume={88 5},
  pages={
          690-698
        }
}
Spleen tyrosine kinase is a new promising target for drug discovery to treat human cancer and inflammatory disorders. A series of pyrazolopyrazine-3-amine and pyrazolopyrimidine-3-amine derivatives was designed and synthesized as new spleen tyrosine kinase inhibitors. The efforts yielded compound 6h with promising spleen tyrosine kinase inhibition in both enzymatic and B-lymphoma cell proliferation assays. Additionally, compound 6h dose dependently inhibited the activation of spleen tyrosine… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.

Similar Papers

Loading similar papers…