3-Pyridylethanolamines: potent and selective human beta 3 adrenergic receptor agonists.

  title={3-Pyridylethanolamines: potent and selective human beta 3 adrenergic receptor agonists.},
  author={Elizabeth M Naylor and Vincent J Colandrea and Mari Rios Candelore and Margaret A. Cascieri and Lawrence F Colwell and Liu Deng and William P Feeney and Michael Forrest and Gary J. Hom and D Euan Macintyre and Catherine D. Strader and Lauri M Tota and Peng Wang and Matthew J Wyvratt and Michael Hallsworth Greg Fisher and Ann Weber},
  journal={Bioorganic & medicinal chemistry letters},
  volume={8 21},
The 3-pyridylethanolamine L-757,793 is a potent beta 3 AR agonist (EC50 6.3 nM, 70% activation) with 1,300- and 500-fold selectivity over binding to the beta 1 and beta 2 ARs, respectively. L-757,793 stimulated lipolysis in rhesus monkeys (ED50 0.2 mg/kg) with a maximum response equivalent to that elicited by isoproterenol. 

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