3-Oxa-15-cyclohexyl prostaglandin DP receptor agonists as topical antiglaucoma agents.

@article{Hellberg20023Oxa15cyclohexylPD,
  title={3-Oxa-15-cyclohexyl prostaglandin DP receptor agonists as topical antiglaucoma agents.},
  author={M. Hellberg and R. Conrow and N. Sharif and M. Mclaughlin and J. Bishop and J. Crider and W. Dean and Kevin A DeWolf and D. R. Pierce and V. Sallee and Robert D. Selliah and B. Severns and Steven J. Sproull and Gary W. Williams and P. W. Zinke and P. Klimko},
  journal={Bioorganic \& medicinal chemistry},
  year={2002},
  volume={10 6},
  pages={
          2031-49
        }
}
A series of prostaglandin DP agonists containing a 3-oxa-15-cyclohexyl motif was synthesized and evaluated in several in vitro and in vivo biological assays. The reference compound ZK 118.182 (9beta-chloro-15-cyclohexyl-3-oxa-omega-pentanor PGF(2alpha)) is a potent full agonist at the prostaglandin DP receptor. Saturation of the 13,14 olefin affords AL-6556, which is less potent but is still a full agonist. Replacement of the 9-chlorine with a hydrogen atom or inversion of the carbon 15… Expand
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