3-O-methyldopa administration does not alter fluorodopa transport into the brain.

  title={3-O-methyldopa administration does not alter fluorodopa transport into the brain.},
  author={Mark Guttman and Geraldine Leger and Jesse Cedarbaum and Avinoam Reches and W. S. Woodward and A. C. Evans and Mirko Diksic and Albert Gjedde},
  journal={Annals of neurology},
  volume={31 6},
To determine if 3-O-methyldopa (3OMD) significantly inhibits the transport of 6-[18F]fluorodopa (6-FD) into the brain at the concentration normally encountered during L-dopa administration, we performed 6-FD studies with positron emission tomography in cynomolgus monkeys in the presence and absence of 3OMD. Infusion of 3OMD was designed to produce plasma concentrations equivalent to those seen in patients on chronic L-dopa therapy. Plasma 3OMD levels of 39 +/- 4 microM did not alter the blood… CONTINUE READING
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