3-O-acetyloleanolic acid induces apoptosis in human colon carcinoma HCT-116 cells.

@article{Yoo20123OacetyloleanolicAI,
  title={3-O-acetyloleanolic acid induces apoptosis in human colon carcinoma HCT-116 cells.},
  author={Ki Hyun Yoo and Jong-Hwa Park and En Ji Cui and Kyung Il Kim and Joo Yun Kim and Jiyoung Kim and Seong Gil Hong and Nam In Baek and In Sik Chung},
  journal={Phytotherapy research : PTR},
  year={2012},
  volume={26 10},
  pages={
          1541-6
        }
}
The cytotoxic effect of 3-O-acetyloleanolic acid, an oleanolic acid derivative isolated from the seeds of Vigna sinensis K., was investigated in human colon carcinoma HCT-116 cells. 3-O-acetyloleanolic acid dose-dependently inhibited the viability of HCT-116 cells. Apoptosis was characterized by detection of cell surface annexin V and sub-G1 apoptotic cell populations. The number of immunostained cells with annexin V-FITC was increased after treatment with 3-O-acetyloleanolic acid. The sub-G1… CONTINUE READING
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Lovro Žiberna, Dunja Šamec, +5 authors Seyed Mohammad Nabavi
  • International journal of molecular sciences
  • 2017
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