3-O-(3',3'-dimethysuccinyl) betulinic acid inhibits maturation of the human immunodeficiency virus type 1 Gag precursor assembled in vitro.

@article{Sakalian20063O33dimethysuccinylBA,
  title={3-O-(3',3'-dimethysuccinyl) betulinic acid inhibits maturation of the human immunodeficiency virus type 1 Gag precursor assembled in vitro.},
  author={Michael Sakalian and Curtis McMurtrey and Frederick J Deeg and Christopher W Maloy and Feng Li and Carl T Wild and Karl Salzwedel},
  journal={Journal of virology},
  year={2006},
  volume={80 12},
  pages={
          5716-22
        }
}
3-O-(3',3'-Dimethysuccinyl) betulinic acid (PA-457) has been shown to potently inhibit human immunodeficiency virus (HIV) replication in culture. In contrast to inhibitors that act upon the viral proteinase, PA-457 appears to block only the final maturational cleavage of p25CA-p2 to p24CA. However, attempts to replicate this effect in vitro using recombinant Gag have failed, leading to the hypothesis that activity is dependent upon the assembly state of Gag. Using a synthesis/assembly system… CONTINUE READING

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