3-Nitrotyrosine and glutathione antioxidant system in patients in the early and late stages of bipolar disorder.

@article{Andreazza20093NitrotyrosineAG,
  title={3-Nitrotyrosine and glutathione antioxidant system in patients in the early and late stages of bipolar disorder.},
  author={Ana C Andreazza and Fl{\'a}vio Kapczinski and M{\'a}rcia Kauer-Sant'Anna and Julio Cesar Walz and David J Bond and Carlos Alberto Saravia Gonçalves and Lionel Trevor Young and Lakshmi N. Yatham},
  journal={Journal of psychiatry & neuroscience : JPN},
  year={2009},
  volume={34 4},
  pages={
          263-71
        }
}
BACKGROUND There has been an increasing interest in the role of oxidative stress in the pathophysiology of bipolar disorder. To explore this further, we evaluated the activity of glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione S-transferase (GST), as well as 3-nitrotyrosine levels and carbonyl content in patients in the early (within 3 years of illness onset) and late (a minimum of 10 years of illness) stages of bipolar disorder. METHODS We matched 30 patients in the… CONTINUE READING

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