3-Nitropropionic acid neurotoxicity is attenuated in copper/zinc superoxide dismutase transgenic mice.

@article{Beal19953NitropropionicAN,
  title={3-Nitropropionic acid neurotoxicity is attenuated in copper/zinc superoxide dismutase transgenic mice.},
  author={Myron Flint Beal and Robert Ferrante and Robert Mikael Henshaw and Russell Thomas Matthews and Pak Hoo Chan and Neil W. Kowall and Charles J. Epstein and J{\"o}rg Bernhard Schulz},
  journal={Journal of neurochemistry},
  year={1995},
  volume={65 2},
  pages={919-22}
}
The mitochondrial toxin 3-nitropropionic acid (3-NP) produces selective striatal lesions in both experimental animals and humans. The pathogenesis of the lesions involves secondary excitotoxicity that may then lead to free radical generation. To test this further we examined the effects of 3-NP in both transgenic (Tg) mice that carry the complete sequence for the human copper/zinc superoxide dismutase (SOD) gene as well as non-Tg littermate controls. The Tg-SOD mice showed a pronounced… CONTINUE READING

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