3-Nitropropionic acid induces ischemic tolerance in gerbil hippocampus in vivo.

  title={3-Nitropropionic acid induces ischemic tolerance in gerbil hippocampus in vivo.},
  author={Toshiyuki Sugino and Kazuhiko Nozaki and Yuko Takagi and N. Hashimoto},
  journal={Neuroscience letters},
  volume={259 1},
Systemic administration of high dose of 3-nitropropionic acid (3-NP), an irreversible inhibitor of succinate dehydrogenase, causes neurodegeneration within the striatum in vivo. However, it has been reported that pretreatment with low dose of 3-NP may increase tolerance to subsequent hypoxia in hippocampal slices. The present study investigated whether ischemic tolerance can be induced in gerbil hippocampus in vivo by low dose of 3-NP. After pretreatment with 3-NP (single i.p. injection of 3 mg… CONTINUE READING


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