3-Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease.

@article{Brouillet20053NitropropionicAA,
  title={3-Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease.},
  author={Emmanuel Brouillet and Carine Jacquard and Nicolas Bizat and David M. Blum},
  journal={Journal of neurochemistry},
  year={2005},
  volume={95 6},
  pages={1521-40}
}
Huntington's disease (HD) is a neurodegenerative disorder caused by a mutation in the gene encoding Huntingtin. The mechanisms underlying the preferential degeneration of the striatum, the most striking neuropathological change in HD, are unknown. Of those probably involved, mitochondrial defects might play an important role. The behavioural and anatomical similarities found between HD and models using the mitochondrial toxin 3-nitropropionic acid (3NP) in rats and primates support this… CONTINUE READING
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