3-Methylindole-induced nasal mucosal damage in mice.

  title={3-Methylindole-induced nasal mucosal damage in mice.},
  author={Matthew A. Turk and William G. Henk and W. Flory},
  journal={Veterinary pathology},
  volume={24 5},
3-Methylindole (3MI) damages nasal olfactory epithelium in mice. Lesions were studied histologically from 30 minutes to 28 days after intraperitoneal injection of 400 mg 3MI/kg. Cellular swelling was apparent in olfactory epithelium by 6 hours after injection of 3MI, while respiratory epithelium was normal. Necrosis of olfactory epithelium and subepithelial glands was diffuse by 48 hours. Subsequent ulceration resulted in epithelial hyperplasia, squamous metaplasia, fibroplasia, and… CONTINUE READING