3-Methylglutaconic aciduria type I causes leukoencephalopathy of adult onset.

@article{Eriguchi20063MethylglutaconicAT,
  title={3-Methylglutaconic aciduria type I causes leukoencephalopathy of adult onset.},
  author={Makoto Eriguchi and Hideko Mizuta and Kazuhiro Kurohara and Momoko Kosugi and Yusuke Yakushiji and Rika Okada and Motohiro Yukitake and Yasuhisa Hasegawa and Shigaki Yamaguchi and Yasuhiro Kuroda},
  journal={Neurology},
  year={2006},
  volume={67 10},
  pages={
          1895-6
        }
}
3-Methylglutaconic amino aciduria (MGA) is characterized by an increased urinary excretion of 3-methylclutaconic acid and 3-methylglutaric acid.1 Four distinct forms are currently recognized: type I (MGA1), 3-methylglutaconyl-CoA hydratase deficiency caused by mutations of the AUH gene1–7; type II, caused by mutations in the tafazzin gene; type III, occurring in a genetic isolate of Iraqi Jews (causative gene has been recently isolated); and type IV, a heterogeneous group. The symptoms usually… CONTINUE READING
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