3-Mercaptopropanol as a traceless linker for chemical and enzymatic synthesis of oligosaccharides.

Abstract

The reducing end of protected carbohydrates can be equipped with a series of aglycones via the photochemical installation of a 3-mercaptoethanol linker. This linker is stable during chemical and enzymatic glycosylation reactions but can be activated readily and efficiently to couple oligosaccharides with different nucleophiles. This approach provides straightforward access to a range of molecules that serve as probes for carbohydrate modifying enzymes. [reaction: see text].

Cite this paper

@article{Merbouh20073MercaptopropanolAA, title={3-Mercaptopropanol as a traceless linker for chemical and enzymatic synthesis of oligosaccharides.}, author={Nabyl Merbouh and Fredrik K Wallner and Oana M Cociorva and Peter H Seeberger}, journal={Organic letters}, year={2007}, volume={9 4}, pages={651-3} }