3-Keto-22-epi-28-nor-cathasterone, a brassinosteroid-related metabolite from Cystoseira myrica.

  title={3-Keto-22-epi-28-nor-cathasterone, a brassinosteroid-related metabolite from Cystoseira myrica.},
  author={A. A. Hamdy and Elsayed Ali Aboutabl and Somayah Sameer and Ahmed Abdel-Fattah Hussein and Ana R D{\'i}az-Marrero and Jos{\'e} Dar{\'i}as and Mercedes Cueto},
  volume={74 12},
Bioassay-guided purification of an ethanolic extract of Cystoseira myrica against HEPG-2 (liver) and HCT116 (colon) human cancer cell lines led to the isolation of 3-keto-22-epi-28-nor-cathasterone, 1 and cholest-4-ene-3,6-dione, 2. This finding allowed us to report for the first time that a brassinosteroid-related metabolite occurs in seaweed. These compounds showed activity in the range of 12.38-1.16 microM with selective activity of compound 2 to liver cancer cell lines. 
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