3-Isoxazolidone--an inhibitor of GABA metabolism.

@article{Gorecki19763IsoxazolidoneanIO,
  title={3-Isoxazolidone--an inhibitor of GABA metabolism.},
  author={D. Gorecki and S. J. Peesker and J. Wood},
  journal={Biochemical pharmacology},
  year={1976},
  volume={25 14},
  pages={
          1653-7
        }
}
Abstract 3-Isoxazolidone, a cyclic analogue of aminooxypropionic acid, was prepared and evaluated for its effect on γ-aminobutyric acid (GABA) metabolism. Its administration to animals resulted in potent inhibitions of brain glutamic acid decarboxylase (GAD) and GABA-α-oxoglutarate aminotransferase (GABA-T) activities. A small but significant increase in brain GABA content was observed. The inhibiting effects varied with the experimental species being greatest in chicks and least in mice. The… Expand
3 Citations
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