3-Hydroxykynurenine and quinolinate: pathogenic synergism in early grade Huntington's disease?

@article{Guidetti20033HydroxykynurenineAQ,
  title={3-Hydroxykynurenine and quinolinate: pathogenic synergism in early grade Huntington's disease?},
  author={Paolo Guidetti and Robert M. Schwarcz},
  journal={Advances in experimental medicine and biology},
  year={2003},
  volume={527},
  pages={
          137-45
        }
}
Huntington's Disease (HD), an inherited neurodegenerative disorder, is caused by an abnormal polyglutamine extension of a protein named huntingtin. This genetic defect is believed to result in heightened neuronal susceptibility to excitotoxic injury, a likely mechanism of neurodegeneration in HD. Two neuroactive kynurenine pathway metabolites, quinolinate (QUIN) and kynurenate (KYNA), have been proposed to play critical roles in the precipitation and prevention, respectively, of excitotoxic… CONTINUE READING
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