3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation.

Abstract

A novel series of 3-hydroxychromones were prepared and found to be CDK inhibitors. Isothiazolidine 1,1-dioxide analogues showed potent CDK1 and CDK2 inhibitory activities and inhibited proliferation of EJ, HCT116, SW620, and MDAMB468 cancer cells. 

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Cite this paper

@article{Lee20073HydroxychromonesAC, title={3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation.}, author={Jinho Lee and Taesik Park and Shinwu Jeong and Kyoung-Hee Kim and Changyong Hong}, journal={Bioorganic & medicinal chemistry letters}, year={2007}, volume={17 5}, pages={1284-7} }