3-Hydroxy-3-methylglutaryl coenzyme a reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture.

@article{Guijarro19983Hydroxy3methylglutarylCA,
  title={3-Hydroxy-3-methylglutaryl coenzyme a reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture.},
  author={C. Guijarro and L. Blanco-Colio and M. Ortego and C. Alonso and A. Ortiz and J. Plaza and C. D{\'i}az and G. H{\'e}rnandez and J. Egido},
  journal={Circulation research},
  year={1998},
  volume={83 5},
  pages={
          490-500
        }
}
Recent evidence suggests that apoptosis may be involved in the control of vascular smooth muscle cell (VSMC) number in atherosclerotic lesions. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors have been reported to induce apoptosis in a variety of tumor cell lines. To evaluate whether these agents also induce apoptosis of VSMCs, cultured rat VSMCs were treated with increasing doses of atorvastatin in the presence of FBS as a survival factor. The presence of apoptosis was… Expand
Cellular Antioxidant Effects of Atorvastatin In Vitro and In Vivo
Fluvastatin Enhances Apoptosis in Cytokine-Stimulated Vascular Smooth Muscle Cells
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 68 REFERENCES
Selective inhibition of isoprenylation of 21-26-kDa proteins by the anticarcinogen d-limonene and its metabolites.
...
1
2
3
4
5
...