3 Homocysteine in the Pathogenesis of Chronic Glaucoma

  title={3 Homocysteine in the Pathogenesis of Chronic Glaucoma},
  author={Mustafa Raad Kadhim and Colin I Clement},
1.1 Metabolic pathway Methionine is one of four amino acids that form succinyl CoA. This sulphur containing amino acid is the source of homocysteine (Hcy). It is converted to S-adenosylmethionine (SAM), the major methyl-group donor in one–carbon metabolism. The synthesis of SAM occurs when methionine condenses with adenosine triphosphate (ATP) by the hydrolysis of all three phosphate bonds. The methyl group attached to the tertiary group in SAM is activated and can be transferred to a variety… CONTINUE READING


Publications referenced by this paper.

vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO prevent stroke (VITATOPS) trial: A randomised, double-blind, parallel, placebo-controlled trial

J BGraeme
  • Lancet Neurol
  • 2010

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