3-Deazaadenosine mitigates arterial remodeling and hypertension in hyperhomocysteinemic mice.

@article{Ovechkin20063DeazaadenosineMA,
  title={3-Deazaadenosine mitigates arterial remodeling and hypertension in hyperhomocysteinemic mice.},
  author={Alexander V. Ovechkin and Neetu Tyagi and Utpal Sen and David Lominadze and Mesia M. Steed and Karni S. Moshal and Suresh C Tyagi},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2006},
  volume={291 5},
  pages={L905-11}
}
Chronic hyperhomocysteinemia (HHcy) is an important factor in development of arterial hypertension. HHcy is associated with activation of matrix metalloproteinases (MMPs); however, it is unclear whether HHcy-dependent extracellular matrix (ECM) accumulation plays a role in arterial hypertrophy and hypertension. We tested the hypothesis that in HHcy the… CONTINUE READING