3-D imaging of islets in obesity: formation of the islet–duct complex and neurovascular remodeling in young hyperphagic mice

@article{Chien20163DIO,
  title={3-D imaging of islets in obesity: formation of the islet–duct complex and neurovascular remodeling in young hyperphagic mice},
  author={H-J Chien and S-J Peng and T-E Hua and C-H Kuo and J H Juang and S-C Tang},
  journal={International Journal of Obesity},
  year={2016},
  volume={40},
  pages={685-697}
}
Background:Obesity and insulin resistance lead to islet hyperplasia. However, how the islet remodeling influences the pancreatic environment and the associated neurovascular networks is largely unknown. The lack of information is primarily due to the difficulty of global visualization of the hyperplasic islet (>200 μm) and the neurovascular environment with high definition.Methods:We modulated the pancreatic optical property to achieve 3-dimensional (3-D) whole-islet histology and to integrate… CONTINUE READING

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