3-D collagen-dependent cell surface expression of MT1-MMP and MMP-2 activation regardless of integrin β1 function and matrix stiffness.

@article{Sakai20113DCC,
  title={3-D collagen-dependent cell surface expression of MT1-MMP and MMP-2 activation regardless of integrin β1 function and matrix stiffness.},
  author={Katsuya Sakai and Takahiro Nakamura and Yoshinori Suzuki and Takafumi Imizu and Kunio Matsumoto},
  journal={Biochemical and biophysical research communications},
  year={2011},
  volume={412 1},
  pages={98-103}
}
Matrix metalloproteinases (MMPs) play roles in spatially dynamic processes, including morphogenesis, wound healing, and tumor invasion. Three-dimensional (3-D) type I collagen stimulates cellular activation of MMP-2, however, the mechanisms underlying this are controversial. The present study investigated mechanisms for 3-D collagen-induced MMP-2 activation in highly invasive human malignant mesothelioma cells. MMP-2 was effectively activated by cells cultured in 3-D collagen but not in 2-D… CONTINUE READING

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